Biocompatibility of acetazolamide pastes in the subcutaneous tissue of rats.
نویسندگان
چکیده
This aim of this study was to investigate the biocompatibility of two experimental acetazolamide (AZ)-based pastes in the subcutaneous tissue of rats. Both pastes contained AZ as the main component in similar concentration. The vehicle in experimental paste 1 was saline, while experimental paste 2 was prepared with propylene glycol. Sixty polyethylene tubes were sealed at one end with gutta-percha (GP), which served as a control. Half of the tubes were filled with paste 1 and half with paste 2. The tubes were implanted in the subcutaneous tissue of 15 rats, being 4 tubes for each animal. The animals were killed 7, 15 and 45 days after surgery and the specimens were processed in laboratory. The histological sections were stained with hematoxylin and eosin and were analyzed by light microscopy. Scores were assigned to level of inflammatory process: 1- none; 2- mild; 3- moderate; 4- severe. The data were analyzed statistically by the Kruskal-Wallis test (p< or =0.05). Paste 1 produced an inflammatory process at 7 days. However, the intensity of this inflammation decreased with time and was nearly absent at 45 days. No statistically significant difference (p>0.05) was observed between the control (GP) and paste 1. However, paste 2 produced inflammatory response at all study periods and differed significantly (p<0.05) from the control. In conclusion, in the present study, the experimental AZ-based paste 1 was considered as biocompatible as the control matrial (GP), while experimental paste 2 was irritating to rat subcutaneous tissue.
منابع مشابه
Biocompatibility comparison of two different sealers AH26 and Apexit: In-vivo animal model
Biocompatibility comparison of two different sealers AH26 and Apexit: In-vivo animal model Dr. Zare Jahromi, M.* - Dr. Razavi, S.M.** - Dr. Tabesh, B.*** *Assistant Professor of Endodontics Dept., Faculty of Dentistry, Isfahan Azad University (Khorasgan). **Assistant Professor of Pathology Dept., Faculty of Dentistry, Isfahan University of Medical Sciences. ***Dentist. Abstract Background & Aim...
متن کاملTHE EFFECT OF 12 WEEKS OF MODERATE INTENSITY CONTINUOUS TRAINING (MICT) ON INFLAMMATORY AND ANGIOGENESIS FACTORS OF VISCERAL AND SUBCUTANEOUS ADIPOSE TISSUE IN OBESE RATS: A SEMI-EXPERIMENTAL STUDY
Background & Aims: Physical activity by modulating angiogenesis in adipose tissue, effects on the entire body metabolic profile. Therefore, the aim of this study was to investigate the effect of 12 weeks of moderate intensity continuous training on VEGF, PEDF and PAI-1 of visceral and subcutaneous adipose tissue in obese rats. Materials & Methods: 15 male Wistar rats were divided into 2 groups...
متن کاملEffect of High Intensity Interval Training on FTO Gene Expression in Subcutaneous Fatty Tissue of Diabetic Wistar Rats
Background: Fat mass and obesity-associated gene (FTO) is directly associated with increased risk of obesity and type 2 diabetes mellitus (T2DM). The purpose of this study was to investigate the effect of 12 weeks of high intensity interval training (HIIT) on FTO expression of subcutaneous fat tissue in T2DM rats. Methods: In this experimental study, twelve males Wistar rats (220±10 g) with T2...
متن کاملPerlipin a Protein of Subcutaneous Adipose Tissue and Pancreatic Bcells Function in Diabetic Rats
Objective: The aim of this study was to compare the three endurance training intensities on the expression of Perlipin A protein in subcutaneous adipose tissue and pancreatic B-cells function in male diabetic rats. Materials and Methods: In this study, 40 healthy male wistar rats were divided into five groups, including diabetic with low intensity endurance training, diabetic with moderate int...
متن کاملComparison of three aerobic exercise methods with different intensities on PPARγ2 gene expression in subcutaneous adipose tissue of male Wistar rats
Background and aims: PPARγ is one of the proteins that plays a very important role in regulating adipose tissue metabolism under physiological and metabolic conditions. Therefore, the aim of this study was to investigate the effect of three aerobic exercise methods of HIIT, HIT and MIT on the PPARγ2 gene expression in the subcutaneous adipose tissue of male Wistar rats. Methods: In this ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Brazilian dental journal
دوره 20 1 شماره
صفحات -
تاریخ انتشار 2009